Changes in the oxygen content of hepatic venous blood during exercise in patients with rheumatic heart disease.
نویسندگان
چکیده
In a study of the effect of exercise on the cardiac output of patients with rheumatic heart disease (1) small and frequent samples of mixed venous blood were drawn from the pulmonary artery during a period of leg exercise and subsequent recovery. Thus a continuous record of the oxygen saturation of this blood and of the arterio-venous oxygen content difference (A-V difference) was obtained. In most patients abnormally large A-V differences were found during exercise and in some the mixed venous blood was less than 10 per cent saturated. This low saturation suggested that even were oxygen completely extracted from the blood perfusing the exercising limbs, there must also be a considerable reduction of blood flow to other regions of the body. This possibility has been investigated by following changes in the oxygen saturation of venous blood returning from various regions and organs of the body at rest and during exercise, by taking frequent blood samples through an intravenous catheter. In this paper, the effect of exercise on the oxygen saturation of hepatic venous blood and on the hepatic arterio-venous oxygen content difference (hepatic A-V difference) in patients with rheumatic heart disease is reported. On the assumption that there is little change in the oxygen uptake of the splanchnic region during brief periods of exercise, alterations in the splanchnic blood flow, inversely related to the changes in the hepatic A-V differences, have been inferred.
منابع مشابه
A study of minute to minute changes of arterio-venous oxygen content difference, oxygen uptake and cardiac output and rate of achievement of a steady state during exercise in rheumatic heart disease.
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 34 7, Part 1 شماره
صفحات -
تاریخ انتشار 1955